编者按:2019年12月7-10日,第61届美国血液学会(ASH)年会将在美国奥兰多举行。作为全球血液学领域规模最大、涵盖最全面的国际学术盛会之一,ASH年汇聚该领域最新、最前沿的研发进展。急性髓系白血病(AML)的治疗方面新药涌现、疗效卓越,BCL2抑制剂Venetoclax(维特克拉)的出现为复发难治的AML患者的治疗带来了新希望。今年ASH大会上,针对AML的治疗又有哪些突破性的研究和成果呢?《肿瘤瞭望》带您提前了解本次大会上即将公布的多项有关Venetoclax 用于AML的重要研究结果。
Part1 老年复发难治AML的新治疗策略
Daver N
Oral Presentation 229
Updated Results from a Phase Ib Study of Venetoclax (Ven) in Combination with Idasanutlin (Idasa) in Elderly Patients (Pts) with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) Ineligible for Cytotoxic Chemotherapy
Venetoclax(VE)联合Idasanutlin(IDASA)用于治疗不适合细胞毒性化疗的老年复发或难治性(R/R)急性髓细胞白血病(AML)IB期研究的最新结果
Type:Oral Presentation Session
时间:Saturday, December 7 2:00 PM
地点:Chapin Theater (W320)
Part2 Venetoclax与FLAG-IDA方案连用,可治疗急性髓系白血病
DiNardo
Oral Presentation 176
A Phase Ib/II Study of the BCL-2 Inhibitor Venetoclax in Combination with Standard Intensive AML Induction/Consolidation Therapy with FLAG-IDA in Patients with Newly Diagnosed or Relapsed/Refractory AML
BCL-2抑制剂Venetoclax联合FLAG-IDA标准强度AML诱导/巩固方案治疗初诊或复发/难治性AML的Ib/II期研究
Type :Oral Presentation Session
时间:Saturday, December 7 12:15 PM
地点:Chapin Theater (W320)
Part3 Venetoclax用于初治AML患者新机理
Chyla B
Oral Presentation 546
Response to Venetoclax in Combination with Low Intensity Therapy (LDAC or HMA) in Untreated Patients with Acute Myeloid Leukemia Patients with IDH, FLT3 and other Mutations and Correlations with BCL2 Family Expression
Venetoclax联合低强度化疗用于伴有IDH、FLT3和其他突变的初治AML患者的治疗反应与BCL2家族表达水平相关
Type :Oral Presentation Session
时间:Monday, December 9 8:15 AM
地点:Valencia A (W415A)